Background: Initial classification of diabetes of young may require revision to improve diagnostic accuracy of\ndifferent forms of diabetes.\nThe aim of our study was to examine markers of beta-cell autoimmunity in a cohort of young (0ââ?¬â??25 years) patients\nwith type 1 diabetes and compare the presentation and course of the disease according to the presence of\npancreatic antibodies.\nMethods: Cross-sectional population-based study was performed covering 100% of pediatric (n = 860) and 70% of\n18ââ?¬â??25 years old adult patients (n = 349) with type 1 diabetes in Lithuania.\nResults: No antibodies (GAD65, IA-2, IAA and ICA) were found in 87 (7.5%) cases. Familial history of diabetes was\nmore frequent in those with antibodies-negative diabetes (24.1 vs. 9.4%, p < 0.001). Gestational age, birth weight\nand age at diagnosis was similar in both groups. Ketosis at presentation was more frequent in patients with\nautoimmune diabetes (88.1 vs. 73.5%, p < 0.05). HbA1c at the moment of investigation was 8.6 (3) vs. 8.7 (2.2)% in\nantibodies-negative and antibodies-positive diabetes groups, respectively, p > 0.05. In the whole cohort, neuropathy\nwas found in 8.8% and nephropathy - in 8.1% of cases, not depending on autoimmunity status. Adjusted for age at\nonset, disease duration and HbA1c, retinopathy was more frequent in antibodies-negative subjects (13.8 vs. 7.8%, p\n< 0.05).\nConclusion: Antibodies-negative pediatric and young adult patients with type 1 diabetes in this study had higher\nincidence of family history of diabetes, higher frequency of retinopathy, less frequent ketosis at presentation, but\nsimilar age at onset, HbA1c, incidence of nephropathy and neuropathy compared to antibodies-positive patients.
Loading....